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Systemic capillary leak syndrome resulting from gemcitabine treatment in renal cell carcinoma: a case report.
[systemic capillary leak syndrome]
In
a
few
cases
,
gemcitabine
(
GCB
)
has
been
shown
to
result
in
systemic
capillary
leak
syndrome
(
SCLS
)
in
the
treatment
of
non-
small
cell
lung
,
pancreatic
,
and
ovarian
carcinomas
.
SCLS
is
a
life-threatening
condition
characterized
by
increased
capillary
permeability
resulting
in
manifest
pulmonary
and
peripheral
edema
.
Usually
SCLS
responds
successfully
to
corticosteroid
therapy
and
diuretics
.
We
present
a
case
where
GCB
treatment
likely
resulted
in
SCLS
in
a
male
patient
with
metastatic
renal
cell
carcinoma
(
RCC
)
in
the
absence
of
predisposing
cardiac
,
pleural
,
or
pulmonary
disease
.