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The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.
[wolf-hirschhorn syndrome]
Histone
lysine
methylation
plays
a
fundamental
role
in
chromatin
organization
.
Although
a
set
of
histone
methyltransferases
have
been
identified
and
biochemically
characterized
,
the
pathological
roles
of
their
dysfunction
in
human
cancers
are
still
not
well
understood
.
In
this
study
,
we
demonstrate
important
roles
of
WHSC
1
L
1
in
human
carcinogenesis
.
Expression
levels
of
WHSC
1
L
1
transcript
were
significantly
elevated
in
various
human
cancers
including
bladder
carcinoma
.
Immunohistochemical
analysis
of
bladder
,
lung
,
and
liver
cancers
confirmed
overexpression
of
WHSC
1
L
1
.
WHSC
1
L
1
-
specific
small
interfering
RNAs
significantly
knocked
down
its
expression
and
resulted
in
suppression
of
proliferation
of
bladder
and
lung
cancer
cell
lines
.
WHSC
1
L
1
knockdown
induced
cell
cycle
arrest
at
the
G
(
2
)
/
M
phase
followed
by
multinucleation
of
cancer
cells
.
Expression
profile
analysis
using
Affymetrix
GeneChip
(
®
)
showed
that
WHSC
1
L
1
affected
the
expression
of
a
number
of
genes
including
CCNG
1
and
NEK
7
,
which
are
known
to
play
crucial
roles
in
the
cell
cycle
progression
at
mitosis
.
As
WHSC
1
L
1
expression
is
significantly
low
in
various
normal
tissues
including
vital
organs
,
WHSC
1
L
1
could
be
a
good
candidate
molecule
for
development
of
novel
treatment
for
various
types
of
cancer
.
