Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Sapropterin Dihydrochloride Mixed With Common Foods and Beverages.
[phenylketonuria]
Sapropterin
dihydrochloride
is
used
to
lower
blood
phenylalanine
levels
in
tetrahydrobiopterin-responsive
phenylketonuria
in
conjunction
with
a
phenylalanine-
restricted
diet
.
This
study
investigated
the
solubility
and
stability
of
sapropterin
tablets
and
a
sapropterin
powder
formulation
when
mixed
in
selected
beverages
and
foods
.
Solubility
was
partial
for
the
tablets
and
complete
for
the
powder
.
The
stability
testing
showed
that
93
%
or
more
of
active
sapropterin
dihydrochloride
is
present
at
1
hour
after
either
tablets
or
powders
are
mixed
with
certain
foods
and
beverages
.
Mixing
sapropterin
powder
with
foods
and
beverages
might
facilitate
its
administration
in
patients
who
have
difficulty
swallowing
the
drug
according
to
prescribing
information
.