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Malignant atrophic papulosis: treatment with aspirin and dipyridamole.
[malignant atrophic papulosis]
On
electron
microscopy
of
the
endothelial
cells
of
a
patient
with
cutaneous
and
CNS
symptoms
of
malignant
atrophic
papulosis
,
paramyxovirus-like
particles
could
be
seen
in
the
cytoplasm
.
These
particles
were
interpreted
as
degenerative
changes
that
were
due
to
ischemia
.
Coagulation
studies
showed
increased
thrombocyte
aggregation
,
and
treatment
with
the
platelet
-suppressive
drugs
,
aspirin
and
dipyridamole
,
was
instituted
.
This
treatment
resulted
in
a
normal
thrombocyte
aggregation
after
eight
months
and
complete
clinical
remission
,
which
still
persisted
four
months
after
cessation
of
therapy
.
Diseases
Validation
Diseases presenting
"which still persisted four months after cessation of therapy"
symptom
malignant atrophic papulosis
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