Intrahepatic cholangiocarcinoma and cholangiolocellular carcinoma in cirrhosis and chronic viral hepatitis.

[cholangiocarcinoma]

Intrahepatic cholangiocarcinoma (ICC ) is the second most common primary liver cancer . Cirrhosis and chronic viral hepatitis are known to be important risk factors for ICC , especially the mass-forming (MF ) type of ICC at the periphery of the liver . Cholangiolocellular carcinoma (CoCC ) is a rare type of primary liver cancer , which is thought to originate from hepatic progenitor or stem cells . CoCC often exhibits the similar MF type at the periphery of the liver , as ICC , and CoCC is also associated with cirrhosis or chronic viral hepatitis . Better survival rates after surgery have been reported for ICC patients with chronic viral hepatitis than for those without chronic viral hepatitis , although survival rates did not differ significantly in relation to cirrhosis . On the other hand , patients with CoCC had better surgical results than those with MF-type ICC . This review summarizes the clinical characteristics and surgical outcomes of ICC and CoCC associated with cirrhosis or chronic viral hepatitis .