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Collagen XVII.
[junctional epidermolysis bullosa]
Collagen
XVII
has
been
identified
as
having
a
role
in
inherited
junctional
epidermolysis
bullosa
non-
Herlitz
(
JEB
-other
,
MIM
#
226650
)
.
The
role
of
collagen
XVII
in
both
autoimmune
and
genetic
blistering
disorders
demonstrates
its
relevance
to
dermal-epidermal
adhesion
.
Collagen
XVII
is
a
major
structural
component
of
the
hemidesmosome
(
HD
)
,
a
highly
specialized
multiprotein
complex
that
mediates
the
anchorage
of
basal
epithelial
cells
to
the
underlying
basement
membrane
in
stratified
,
pseudostratified
,
and
transitional
epithelia
.
This
article
examines
the
genetic
and
pathological
features
of
collagen
XVII
.