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Downregulation of MLL3 in esophageal squamous cell carcinoma is required for the growth and metastasis of cancer cells.
[esophageal squamous cell carcinoma]
The
mixed
lineage
leukemia
3
(
MLL
3
)
,
a
member
of
the
mixed
lineage
leukemia
(
MLL
)
family
,
has
been
reported
to
be
mutated
in
multiple
cancer
types
.
However
,
its
function
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
remains
poorly
understood
.
Here
,
we
found
that
the
expression
of
MLL
3
was
downregulated
in
ESCC
tissues
.
Moreover
,
over-expression
of
MLL
3
in
ESCC
cells
inhibited
cell
proliferation
and
migration
,
while
the
knockdown
expression
of
MLL
3
promoted
the
tumorigenicity
of
ESCC
cells
.
Mechanistically
,
MLL
3
regulated
the
expression
of
multiple
growth
-related
and
migration-related
genes
.
Taken
together
,
our
study
suggested
that
downregulation
of
MLL
3
was
very
important
in
the
progression
of
ESCC
.
