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A random Abstract
Our Project
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Inflammatory myopathies.
[inclusion body myositis]
To
discuss
the
clinical
,
laboratory
,
and
histopathologic
features
and
presumed
pathogenic
mechanisms
of
the
four
major
categories
of
idiopathic
inflammatory
myopathy
,
namely
dermatomyositis
,
polymyositis
,
immune-mediated
necrotizing
myopathy
,
and
inclusion
body
myositis
.
Dermatomyositis
,
polymyositis
,
necrotizing
myopathy
,
and
inclusion
body
myositis
are
clinically
,
histologically
,
and
pathogenically
distinct
.
Polymyositis
is
a
T
cell-mediated
disorder
directed
against
muscle
fibers
.
The
pathogenesis
of
dermatomyositis
,
necrotizing
myopathy
,
and
inclusion
body
myositis
are
unknown
.
Dermatomyositis
,
polymyositis
,
and
necrotizing
myopathy
are
generally
,
but
not
always
,
responsive
to
immunosuppressive
therapy
,
in
contrast
to
inclusion
body
myositis
,
which
is
generally
refractory
to
therapy
.
The
pattern
of
muscle
weakness
,
other
clinical
features
(
eg
,
rash
,
concurrent
interstitial
lung
disease
)
,
laboratory
features
(
creatine
kinase
,
autoantibodies
)
,
and
muscle
biopsies
are
useful
in
distinguishing
subtypes
of
inflammatory
myopathy
and
in
guiding
treatment
.
More
research
is
necessary
to
unravel
the
exact
pathogenic
bases
of
these
myopathies
and
identify
better
treatments
.
Diseases
Validation
Diseases presenting
"namely dermatomyositis"
symptom
inclusion body myositis
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