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Molecular and phenotypic expression of decorin as modulator of angiogenesis in human potentially malignant oral lesions and oral squamous cell carcinomas.
[oral submucous fibrosis]
Decorin
is
an
extracellular
matrix
,
multifunctional
small
proteoglycan
molecule
in
tumor
stroma
that
has
been
shown
to
be
modulator
of
angiogenesis
.
No
clinical
data
is
available
so
far
on
decorin
expression
and
survival
outcome
of
oral
cancer
.
The
aim
of
the
present
study
was
to
examine
molecular
and
phenotypic
expression
of
two
angiogenesis
modulators
viz
.
decorin
and
vascular
endothelial
growth
factor
-
A
(
VEGF-A
)
in
human
potentially
malignant
oral
lesions
(
PMOLs
)
and
oral
squamous
cell
carcinomas
(
OSCC
)
in
relation
to
clinico-pathological
variables
and
survival
outcome
.
Tissue
biopsies
were
obtained
from
72
PMOLs
,
108
OSCC
and
52
healthy
controls
.
The
PMOLs
included
cases
of
leukoplakias
and
oral
submucous
fibrosis
.
Immunohistochemistry
was
performed
using
antibodies
against
decorin
,
VEGF-A
and
CD-
31
.
Messenger-ribonucleic
acid
(
mRNA
)
expression
was
analyzed
by
using
real-time
polymerase
chain
reaction
.
Cytoplasmic
staining
of
decorin
was
observed
in
the
basal
layer
of
epithelium
in
53
(
73
.
61
%
)
cases
of
PMOLs
and
in
peritumoral
stroma
in
55
(
50
.
92
%
)
cases
of
OSCC
.
None
of
the
cases
showed
nuclear
expression
of
decorin
.
Decorin
expression
both
at
phenotypic
and
molecular
level
was
found
to
be
down-regulated
from
PMOLs
to
OSCC
.
Lymph
node
metastasis
and
reduced
decorin
expression
independently
correlated
with
overall
survival
in
OSCC
.
VEGF-A
expression
had
no
significant
impact
on
survival
outcome
.
Micro
vessel
density
and
VEGF-A
expression
were
significantly
associated
with
reduced
decorin
expression
in
tumor
stroma
suggesting
,
decorin
as
angiogenic
modulator
in
OSCC
.
Down-regulation
of
decorin
expression
and
the
presence
of
lymph
node
metastasis
were
adverse
factor
independently
affecting
overall
survival
in
OSCC
.