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Blood flow restricted resistance training attenuates myostatin gene expression in a patient with inclusion body myositis.
[inclusion body myositis]
Inclusion
body
myositis
is
a
rare
idiopathic
inflammatory
myopathy
that
produces
extreme
muscle
weakness
.
Blood
flow
restricted
resistance
training
has
been
shown
to
improve
muscle
strength
and
muscle
hypertrophy
in
inclusion
body
myositis
.
The
aim
of
this
study
was
to
evaluate
the
effects
of
a
resistance
training
programme
on
the
expression
of
genes
related
to
myostatin
(
MSTN
)
signalling
in
one
inclusion
body
myositis
patient
.
A
65
-
year
-old
man
with
inclusion
body
myositis
underwent
blood
flow
restricted
resistance
training
for
12
weeks
.
The
gene
expression
of
MSTN
,
follistatin
,
follistatin
-like
3
,
activin
II
B
receptor
,
SMAD-
7
,
MyoD
,
FOXO-
3
,
and
MURF-
2
was
quantified
.
After
12
weeks
of
training
,
a
decrease
(
25
%
)
in
MSTN
mRNA
level
was
observed
,
whereas
follistatin
and
follistatin
-like
3
gene
expression
increased
by
40
%
and
70
%
,
respectively
.
SMAD-
7
mRNA
level
was
augmented
(
20
%
)
.
FOXO-
3
and
MURF-
2
gene
expression
increased
by
40
%
and
20
%
,
respectively
.
No
change
was
observed
in
activin
II
B
receptor
or
MyoD
gene
expression
.
Blood
flow
restricted
resistance
training
attenuated
MSTN
gene
expression
and
also
increased
expression
of
myostatin
endogenous
inhibitors
.
Blood
flow
restricted
resistance
training
evoked
changes
in
the
expression
of
genes
related
to
MSTN
signalling
pathway
that
could
in
part
explain
the
muscle
hypertrophy
previously
observed
in
a
patient
with
inclusion
body
myositis
.
Diseases
Validation
Diseases presenting
"muscle weakness"
symptom
alexander disease
canavan disease
coats disease
cohen syndrome
cystinuria
familial mediterranean fever
focal myositis
inclusion body myositis
neuralgic amyotrophy
pyomyositis
severe combined immunodeficiency
systemic capillary leak syndrome
thoracic outlet syndrome
triple a syndrome
von hippel-lindau disease
This symptom has already been validated