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Circulating antimüllerian hormone levels in boys decline during early puberty and correlate with inhibin B.
[kallmann syndrome]
To
investigate
peripheral
levels
of
inhibin
B
and
antimüllerian
hormone
(
AMH
)
in
boys
during
peripuberty
and
in
patients
with
congenital
hypogonadotropic
hypogonadism
(
HH
)
.
Randomized
,
placebo-controlled
trial
(
peripubertal
boys
)
;
and
cross-sectional
clinical
study
(
males
with
HH
)
.
University
central
hospital
.
Twenty
-
eight
peripubertal
boys
with
idiopathic
short
stature
(
ISS
)
,
19
males
with
Kallmann
syndrome
.
Letrozole
(
2
.
5
mg
/
day
)
or
placebo
in
boys
with
ISS
for
2
years
.
Longitudinal
follow-up
observation
of
serum
AMH
and
its
relationship
with
inhibin
B
during
early
puberty
and
the
influence
of
high
(
letrozole-treated
boys
)
and
low
(
males
with
HH
)
gonadotropin
exposure
on
circulating
AMH
.
In
boys
with
ISS
receiving
placebo
,
the
decrease
in
AMH
levels
and
the
increase
in
inhibin
B
levels
were
correlated
.
The
serum
AMH
level
had
already
declined
before
a
clinically
significant
increase
in
testis
volume
or
serum
testosterone
occurred
.
Letrozole
did
not
appear
to
modulate
the
decline
in
AMH
.
The
AMH
levels
were
lower
in
boys
and
young
adults
with
Kallmann
syndrome
and
prepubertal
testes
(
mean
:
20
.
9
±
4
.
7
ng
/
mL
,
n
=
6
)
as
compared
with
prepubertal
ISS
boys
(
102
.
3
±
11
.
9
ng
/
mL
)
.
The
gonadotropin-mediated
early
pubertal
increase
in
inhibin
B
is
tightly
coupled
to
decrease
in
AMH
levels
and
may
reflect
androgen-mediated
differentiation
of
Sertoli
cells
.
Profound
gonadotropin
deficiency
is
associated
with
low
AMH
levels
,
suggesting
impaired
development
of
the
Sertoli
cell
population
.
