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Magnetic resonance velocity mapping of 3D cerebrospinal fluid flow dynamics in hydrocephalus: preliminary results.
[hydrocephalus with stenosis of the aqueduct of sylvius]
To
investigate
the
detectability
of
CSF
flow
alterations
in
the
ventricular
system
of
patients
with
hydrocephalus
using
time-resolved
3
D
MR
velocity
mapping
.
MR
velocity
mapping
was
performed
in
21
consecutive
hydrocephalus
patients
and
21
age-matched
volunteers
using
a
3
D
phase-contrast
(
PC
)
sequence
.
Velocity
vectors
and
particle
path
lines
were
calculated
for
visualisation
of
flow
dynamics
.
CSF
flow
was
classified
as
"
hypomotile
flow
"
if
it
showed
attenuated
dynamics
and
as
"
hypermotile
flow
"
if
it
showed
increased
dynamics
compared
with
volunteers
.
Diagnostic
efficacy
was
compared
with
routine
2
D
cine
PC
-MRI
.
Seven
patients
showed
hypomotile
CSF
flow
:
six
had
non-
communicating
hydrocephalus
due
to
aqueductal
stenosis
.
One
showed
oscillating
flow
between
the
lateral
ventricles
after
craniotomy
for
intracranial
haemorrhage
.
Seven
patients
showed
normal
flow
:
six
had
hydrocephalus
ex
vacuo
due
to
brain
atrophy
.
One
patient
who
underwent
ventriculostomy
10
years
ago
showed
a
flow
path
through
the
opening
.
Seven
patients
showed
hypermotile
flow
:
three
had
normal
pressure
hydrocephalus
,
three
had
dementia
,
and
in
one
the
diagnosis
remained
unclear
.
The
diagnostic
efficacy
of
velocity
mapping
was
significantly
higher
except
for
that
of
aqueductal
stenosis
.
Our
approach
may
be
useful
for
diagnosis
,
therapy
planning
,
and
follow-up
of
different
kinds
of
hydrocephalus
.
Diseases
Validation
Diseases presenting
"brain atrophy"
symptom
cadasil
canavan disease
cushing syndrome
gm1 gangliosidosis
hydrocephalus with stenosis of the aqueduct of sylvius
wolf-hirschhorn syndrome
zellweger syndrome
This symptom has already been validated