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The fungal DNA examination is useful as a sensitive parameter for the initiation and the quit of antifungal therapy in immunocompromised pediatric patients after surgery.
[megacystis-microcolon-intestinal hypoperistalsis syndrome]
The
purpose
of
this
study
is
whether
the
fungal
deoxyribonucleic
acid
(
DNA
)
examination
is
useful
as
a
sensitive
parameter
for
pediatric
surgical
patients
with
mycosis
.
The
eleven
episodes
of
five
cases
(
4
cases
;
progressive
liver
disease
after
biliary
atresia
operation
,
1
case
;
short
bowel
syndrome
and
long
term
total
parenteral
nutrition
with
megacystis
microcolon
intestinal
hypoperistalsis
syndrome
)
with
mycosis
were
divided
into
two
groups
according
to
the
difference
of
therapeutic
protocols
.
The
sensitivity
of
fungal
DNA
examination
,
serum
Candida
antigen
level
,
plasma
beta
-
D
glucan
level
,
and
blood
culture
were
evaluated
at
the
onset
of
infection
and
at
the
quit
of
antifungal
medication
under
the
protocols
respectively
.
The
duration
of
medication
and
the
medication
free
interval
in
two
groups
were
compared
.
The
6
episodes
(
3
cases
)
were
diagnosed
and
treated
under
the
protocol
not
including
fungal
DNA
examination
,
while
the
5
episodes
(
2
cases
)
under
the
protocol
including
fungal
DNA
examination
.
The
occurrence
rate
was
not
significant
.
The
sensitivity
of
fungal
DNA
examination
was
complete
,
but
others
were
not
.
Using
the
fungal
DNA
examination
,
the
duration
of
medication
became
significantly
short
.
We
conclude
that
the
fungal
DNA
examination
could
be
a
sensitive
parameter
not
only
to
start
but
to
quit
antifungal
medication
in
pediatric
patients
with
mycosis
.