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A retrospective study of paclitaxel combining nedaplatin chemotherapy for esophageal cancer.
[esophageal squamous cell carcinoma]
The
aim
of
this
study
was
to
evaluate
the
efficacy
and
tolerability
of
the
combination
of
paclitaxel
and
nedaplatin
in
patients
with
advanced
esophageal
cancer
.
Patients
(
n
=
310
)
with
recurrent
or
metastatic
esophageal
squamous
cell
carcinoma
,
who
had
a
maximum
of
one
previous
chemotherapy
regimen
,
were
enrolled
in
this
study
.
All
patients
had
bidimensionally
measurable
disease
.
Patients
received
175
mg
/
m
of
paclitaxel
over
a
3
h
infusion
,
followed
by
nedaplatin
80
mg
/
m
in
a
1
h
infusion
on
day
1
every
3
weeks
for
up
to
6
treatment
cycles
.
The
overall
response
rate
was
47
.
7
%
,
with
complete
and
partial
response
rates
of
6
.
1
and
41
.
7
%
,
respectively
.
The
median
time
to
progression
for
all
patients
was
6
.
8
months
(
95
%
confidence
interval
,
6
.
2
-
7
.
4
months
)
and
the
3
-
year
disease-free
survival
probability
was
3
(
15
.
8
%
)
.
The
major
toxicity
observed
was
cumulative
neutropenia
,
with
29
%
patients
developing
grade
4
toxicity
.
There
was
no
treatment-related
death
.
The
most
common
nonhematologic
toxicity
encountered
with
this
regimen
was
pain
and
cumulative
peripheral
neuropathy
,
with
26
%
patients
experiencing
grade
2
or
3
toxicity
.
The
combination
of
paclitaxel
and
nedaplatin
shows
significant
antitumor
activity
and
a
favorable
toxicity
profile
in
patients
with
metastatic
carcinoma
of
esophageal
cancer
.
Diseases
Validation
Diseases presenting
"pain"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
aniridia
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital diaphragmatic hernia
congenital toxoplasmosis
cushing syndrome
cutaneous mastocytosis
cystinuria
dedifferentiated liposarcoma
dentin dysplasia
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial mediterranean fever
focal myositis
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
junctional epidermolysis bullosa
kabuki syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
malignant atrophic papulosis
neuralgic amyotrophy
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
pleomorphic liposarcoma
primary hyperoxaluria type 1
proteus syndrome
pyomyositis
scrub typhus
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
trochlear dysplasia
typhoid
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
wolf-hirschhorn syndrome
This symptom has already been validated
