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A random Abstract
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Lentiviral vectors for cancer immunotherapy and clinical applications.
[x-linked adrenoleukodystrophy]
The
success
of
immunotherapy
against
infectious
diseases
has
shown
us
the
powerful
potential
that
such
a
treatment
offers
,
and
substantial
work
has
been
done
to
apply
this
strategy
in
the
fight
against
cancer
.
Cancer
is
however
a
fiercer
opponent
than
pathogen-caused
diseases
due
to
natural
tolerance
towards
tumour
associated
antigens
and
tumour-induced
immunosuppression
.
Recent
gene
therapy
clinical
trials
with
viral
vectors
have
shown
clinical
efficacy
in
the
correction
of
genetic
diseases
,
HIV
and
cancer
.
The
first
successful
gene
therapy
clinical
trials
were
carried
out
with
onco
(
γ-
)
retroviral
vectors
but
oncogenesis
by
insertional
mutagenesis
appeared
as
a
serious
complication
.
Lentiviral
vectors
have
emerged
as
a
potentially
safer
strategy
,
and
recently
the
first
clinical
trial
of
patients
with
advanced
leukemia
using
lentiviral
vectors
has
proven
successful
.
Additionally
,
therapeutic
lentivectors
have
shown
clinical
efficacy
for
the
treatment
of
HIV
,
X-
linked
adrenoleukodystrophy
,
and
β-thalassaemia
.
This
review
aims
at
describing
lentivectors
and
how
they
can
be
utilized
to
boost
anti-tumour
immune
responses
by
manipulating
the
effector
immune
cells
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated