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MMSET is overexpressed in cancers: link with tumor aggressiveness.
[wolf-hirschhorn syndrome]
MMSET
is
expressed
ubiquitously
in
early
development
and
its
deletion
is
associated
with
the
malformation
syndrome
called
Wolf-
Hirschhorn
syndrome
.
It
is
involved
in
the
t
(
4
;
14
)
(
p
16
;
q
32
)
chromosomal
translocation
,
which
is
the
second
most
common
translocation
in
multiple
myeloma
(
MM
)
and
is
associated
with
the
worst
prognosis
.
MMSET
expression
has
been
shown
to
promote
cellular
adhesion
,
clonogenic
growth
and
tumorigenicity
in
multiple
myeloma
.
MMSET
expression
has
been
recently
shown
to
increase
with
ascending
tumor
proliferation
activity
in
glioblastoma
multiforme
.
These
data
demonstrate
that
MMSET
could
be
implicated
in
tumor
emergence
and
/
or
progression
.
Therefore
,
we
compared
the
expression
of
MMSET
in
40
human
tumor
types--
brain
,
epithelial
,
lymphoid--
to
that
of
their
normal
tissue
counterparts
using
publicly
available
gene
expression
data
,
including
the
Oncomine
Cancer
Microarray
database
.
We
found
significant
overexpression
of
MMSET
in
15
cancers
compared
to
their
normal
counterparts
.
Furthermore
MMSET
is
associated
with
tumor
aggressiveness
or
prognosis
in
many
types
of
these
aforementioned
cancers
.
Taken
together
,
these
data
suggest
that
MMSET
potentially
acts
as
a
pathogenic
agent
in
many
cancers
.
The
identification
of
the
targets
of
MMSET
and
their
role
in
cell
growth
and
survival
will
be
key
to
understand
how
MMSET
is
associated
with
tumor
development
.