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Two cases of neuroendocrine carcinoma of the gallbladder.
[carcinoma of the gallbladder]
Neuroendocrine
carcinoma
(
NEC
)
of
the
gallbladder
is
a
rare
subtype
of
gallbladder
tumor
.
Here
,
we
report
two
cases
of
NEC
in
two
patients
initially
suspected
to
have
gallbladder
carcinoma
.
No
specific
symptoms
or
abnormal
blood
test
results
were
observed
preoperatively
.
Abdominal
computed
tomography
scans
indicated
intraluminal
masses
in
the
gallbladder
and
lymph
node
enlargement
in
the
hepatic
hilum
.
Radical
cholecystectomy
and
regional
lymphadenectomy
were
performed
.
The
first
patient
also
presented
with
liver
invasion
and
therefore
underwent
resection
of
liver
segment
IV
.
A
diagnosis
of
NEC
was
made
upon
postoperative
pathological
examination
and
immunohistochemical
staining
according
to
the
WHO
Classification
of
Tumors
of
the
Digestive
System
(
2010
)
.
One
tumor
was
identified
as
poorly
differentiated
NEC
and
the
other
as
poorly
differentiated
mixed
adenoneuroendocrine
carcinoma
.
Immunohistochemical
staining
data
from
both
tumors
showed
positivity
for
chromogranin
A
and
synaptophysin
.
The
first
patient
received
4
cycles
of
chemotherapy
consisting
of
cisplatin
and
etoposide
.
No
metastases
or
recurrence
were
observed
12
mo
following
surgery
.
The
second
patient
refused
chemotherapy
and
presented
with
tumor
recurrence
4
mo
after
surgery
.
In
conclusion
,
NEC
of
the
gallbladder
is
an
aggressive
tumor
and
the
identification
of
a
standardized
optimal
treatment
still
requires
further
research
.
Our
experience
together
with
published
studies
suggests
that
radical
surgery
and
adjuvant
chemotherapy
may
improve
the
prognosis
.
