Two cases of hepatic adenomas in patients with Wolf-Hirschhorn syndrome: a new rare complication?

[wolf-hirschhorn syndrome]

Wolf-Hirschhorn syndrome (WHS ) is a rare microdeletion syndrome associated with a characteristic facial appearance , failure to thrive , psychomotor delays , and various major malformations of internal organs ; many medical complications have been described (feeding difficulties , epilepsy , hearing problems ). Benign or malignant oncologic problems are not a typical feature of the natural history of these patients . We report on two patients with WHS patients in whom hepatic adenoma (HA ) were diagnosed during adolescence . The clinical evolution of liver involvement was different between the two . We discuss the possibility of considering HA as a rare medical problem in the follow-up of WHS patients . © 2013 Wiley Periodicals , Inc .