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MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
MicroRNAs
(
miRNAs
)
play
a
critical
role
in
development
and
progression
of
cancers
.
Deregulation
of
MicroRNA-
9
(
miR-
9
)
has
been
documented
in
many
types
of
cancers
but
their
role
in
the
development
of
esophageal
squamous
cell
carcinoma
(
ESCC
)
has
not
been
studied
.
This
study
aimed
to
investigate
the
effect
of
miR-
9
in
esophageal
cancer
metastasis
.
The
up-regulation
of
miR-
9
was
frequently
detected
in
primary
ESCC
tumor
tissue
,
which
was
significantly
associated
with
clinical
progression
(
P
=
0
.
022
)
,
lymph
node
metastasis
(
P
=
0
.
007
)
and
poor
overall
survival
(
P
<
0
.
001
)
.
Functional
study
demonstrated
that
miR-
9
promoted
cell
migration
and
tumor
metastasis
,
which
were
effectively
inhibited
when
expression
of
miR-
9
was
silenced
.
Moreover
,
we
demonstrated
that
miR-
9
interacted
with
the
3
'
-
untranslated
region
of
E
-
cadherin
and
down-regulated
its
expression
,
which
induced
β-catenin
nuclear
translocation
and
subsequently
up-regulated
c-myc
and
CD
44
expression
.
In
addition
,
miR-
9
induced
epithelial-mesenchymal
transition
(
EMT
)
in
ESCC
,
a
key
event
in
tumor
metastasis
.
Taken
together
,
our
study
demonstrates
that
miR-
9
plays
an
important
role
in
ESCC
metastasis
by
activating
β-catenin
pathway
and
inducing
EMT
via
targeting
E
-
cadherin
.
Our
study
also
suggests
miR-
9
can
be
served
as
a
new
independent
prognostic
marker
and
/
or
as
a
novel
potential
therapeutic
target
for
ESCC
.