Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
[Clinicopathologic features and differential diagnosis of splenic B-cell marginal zone lymphoma involving bone marrow].
[waldenström macroglobulinemia]
To
study
the
clinicopathologic
features
and
differential
diagnosis
of
splenic
B-
cell
marginal
zone
lymphoma
(
SMZL
)
involving
bone
marrow
.
The
clinical
and
pathologic
features
of
22
patients
with
SMZL
were
retrospectively
studied
.
Immunophenotypic
analysis
was
carried
out
by
flow
cytometry
and
immunohistochemistry
.
Immunoglobulin
heavy
chain
rearrangement
study
was
performed
using
polymerase
chain
reaction-based
method
.
Villous
lymphocytes
were
found
in
peripheral
blood
smears
of
11
/
18
of
the
patients
.
In
bone
marrow
aspirates
,
lymphocytosis
(
>
20
%
)
was
demonstrated
in
15
cases
(
15
/
18
)
and
villous
lymphocytes
in
6
cases
(
6
/
18
)
.
Flow
cytometry
showed
CD
19
(
+
)
CD
2
0
(
+
)
FMC
7
(
+
)
CD
22
(
+
)
CD
10
(
-
)
CD
2
(
-
)
CD
3
(
-
)
CD
7
(
-
)
in
18
cases
.
Bone
marrow
biopsies
of
all
the
22
patients
revealed
various
degrees
and
patterns
of
neoplastic
infiltration
,
as
follows
:
mild
(
4
cases
,
18
.
2
%
)
,
moderate
(
11
cases
,
50
.
0
%
)
or
severe
(
7
cases
,
31
.
8
%
)
;
intrasinusoidal
(
16
cases
,
72
.
7
%
)
,
interstitial
(
14
cases
,
63
.
6
%
)
,
nodular
(
11
cases
,
50
.
0
%
)
or
diffuse
(
1
case
,
4
.
5
%
)
.
Reactive
germinal
center
formation
(
CD
2
3
(
+
)
bcl-
2
(
-
)
)
was
found
in
2
cases
(
91
.
0
%
)
.
Immunohistochemical
study
showed
the
following
results
:
CD
2
0
(
+
)
PAX
5
(
+
)
CD
3
(
-
)
CD
5
(
-
)
CD
10
(
-
)
cyclin
D
1
(
-
)
CD
2
3
(
-
)
CD
4
3
(
-
)
Annexin
A
1
(
-
)
CD
11
C
(
-
)
CD
2
5
(
-
)
in
all
the
22
cases
,
CD
38
(
+
)
in
2
cases
(
9
.
1
%
)
and
CD
138
(
+
)
in
2
cases
(
9
.
1
%
)
.
Different
and
overlapping
patterns
of
bone
marrow
involvement
are
observed
in
SMZL
.
As
the
histologic
and
immunophenotypic
features
are
not
specific
to
SMZL
,
distinction
from
other
types
of
mature
B-
cell
lymphomas
is
necessary
.
Diseases
Validation
Diseases presenting
"bone marrow involvement"
symptom
cutaneous mastocytosis
esophageal squamous cell carcinoma
waldenström macroglobulinemia
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom
