Rare Diseases Symptoms Automatic Extraction

Predictors of mortality in children with typhoid ileal perforation in a Nigerian tertiary hospital.

[typhoid]

Childhood typhoid ileal perforation is associated with high morbidity and mortality. Our aim was to ascertain the predictors of survival in children.This is a tertiary hospital-based retrospective review of patients aged ≤15 years managed for typhoid ileal perforations between January 2005 and December 2013. The details of their biodata, potential risk factors and outcome were evaluated.Forty-five children out of a total of 97 with typhoid fever had typhoid ileal perforation. The age range was 2-15 years, mean (±SD) = 9.3 (±3.31) years, median = 10 years. There were more males than females (26:19). Thirty-nine (86.7 %) patients were >5 years old. There were nine deaths (20 % mortality). The mean (±SD) age of survivors was 9.8 (±2.9) years and 7.1 (±4.2) for non-survivors (p = 0.026). The duration of illness at presentation, gender, admission temperature, nutritional status and packed cell volume, perforation-operation interval, number of perforations, surgical procedure, and the duration of surgery did not statistically influence survival (p > 0.05). The age of the patients and burst abdomen attained statistical significance (p < 0.05).The patients' age and postoperative burst abdomen were significant determinants of survival in children with typhoid ileal perforation.

Diseases presenting "high morbidity" symptom

  • congenital diaphragmatic hernia
  • cystinuria
  • heparin-induced thrombocytopenia
  • legionellosis
  • locked-in syndrome
  • megacystis-microcolon-intestinal hypoperistalsis syndrome
  • systemic capillary leak syndrome
  • typhoid
  • zellweger syndrome

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