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Characterization based on the 56-Kda type-specific antigen gene of Orientia tsutsugamushi genotypes isolated from Leptotrombidium mites and the rodent host post-infection.
[scrub typhus]
Abstract
.
Characterization
of
the
56
-
kDa
type
-
specific
antigen
(
TSA
)
genes
of
Orientia
tsutsugamushi
(
OT
)
from
three
naturally
infected
,
laboratory-reared
mite
colonies
comprising
three
species
(
Leptotrombidium
deliense
[
Ld
]
,
Leptotrombidium
imphalum
[
Li
]
,
and
Leptotrombidium
chiangraiensis
[
Lc
]
)
has
revealed
the
presence
of
single
and
coexisting
OT
genotypes
found
in
individual
chiggers
.
The
Karp
genotype
was
found
in
all
of
the
chiggers
examined
,
whereas
Gilliam
and
UT
302
genotypes
were
only
observed
in
combination
with
the
Karp
genotype
.
From
analysis
of
these
OT
genotypes
after
transmission
from
chiggers
to
mice
it
was
determined
that
with
the
Lc
and
Li
mites
,
the
OT
genotype
composition
in
the
rodent
spleens
post-infection
had
not
changed
and
therefore
resembled
that
observed
in
the
feeding
chiggers
.
However
,
only
the
Karp
genotype
was
found
in
rodents
after
feeding
by
Ld
chiggers
carrying
Karp
and
Gilliam
genotypes
.
The
current
findings
reveal
a
complex
association
among
the
host
,
pathogen
,
and
vector
.