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High seroprevalence of Mycoplasma pneumoniae IgM in acute Q fever by enzyme-linked immunosorbent assay (ELISA).
[scrub typhus]
Q
fever
is
serologically
cross-reactive
with
other
intracellular
microorganisms
.
However
,
studies
of
the
serological
status
of
Mycoplasma
pneumoniae
and
Chlamydophila
pneumoniae
during
Q
fever
are
rare
.
We
conducted
a
retrospective
serological
study
of
M
.
pneumoniae
and
C
.
pneumoniae
by
enzyme-linked
immunosorbent
assay
(
ELISA
)
,
a
method
widely
used
in
clinical
practice
,
in
102
cases
of
acute
Q
fever
,
39
cases
of
scrub
typhus
,
and
14
cases
of
murine
typhus
.
The
seropositive
(
57
.
8
%
,
7
.
7
%
,
and
0
%
,
p
<
0
.
001
)
and
seroconversion
rates
(
50
.
6
%
,
8
.
8
%
,
and
0
%
,
p
<
0
.
001
)
of
M
.
pneumoniae
IgM
,
but
not
M
.
pneumoniae
IgG
and
C
.
pneumoniae
IgG
/
IgM
,
in
acute
Q
fever
were
significantly
higher
than
in
scrub
typhus
and
murine
typhus
.
Another
ELISA
kit
also
revealed
a
high
seropositivity
(
49
.
5
%
)
and
seroconversion
rate
(
33
.
3
%
)
of
M
.
pneumoniae
IgM
in
acute
Q
fever
.
The
temporal
and
age
distributions
of
patients
with
positive
M
.
pneumoniae
IgM
were
not
typical
of
M
.
pneumoniae
pneumonia
.
Comparing
acute
Q
fever
patients
who
were
positive
for
M
.
pneumoniae
IgM
(
59
cases
)
with
those
who
were
negative
(
43
cases
)
,
the
demographic
characteristics
and
underlying
diseases
were
not
different
.
In
addition
,
the
clinical
manifestations
associated
with
atypical
pneumonia
,
including
headache
(
71
.
2
%
vs
.
81
.
4
%
,
p
=
0
.
255
)
,
sore
throat
(
8
.
5
%
vs
.
16
.
3
%
,
p
=
0
.
351
)
,
cough
(
35
.
6
%
vs
.
23
.
3
%
,
p
=
0
.
199
)
,
and
chest
x-
ray
suggesting
pneumonia
(
19
.
3
%
vs
.
9
.
5
%
,
p
=
0
.
258
)
,
were
unchanged
between
the
two
groups
.
Clinicians
should
be
aware
of
the
high
seroprevalence
of
M
.
pneumoniae
IgM
in
acute
Q
fever
,
particularly
with
ELISA
kits
,
which
can
lead
to
misdiagnosis
,
overestimations
of
the
prevalence
of
M
.
pneumoniae
pneumonia
,
and
underestimations
of
the
true
prevalence
of
Q
fever
pneumonia
.
Diseases
Validation
Diseases presenting
"pneumonia"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
allergic bronchopulmonary aspergillosis
alpha-thalassemia
classical phenylketonuria
cohen syndrome
congenital diaphragmatic hernia
heparin-induced thrombocytopenia
hydrocephalus with stenosis of the aqueduct of sylvius
junctional epidermolysis bullosa
lamellar ichthyosis
legionellosis
liposarcoma
lymphangioleiomyomatosis
monosomy 21
oculocutaneous albinism
omenn syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
scrub typhus
severe combined immunodeficiency
triple a syndrome
waldenström macroglobulinemia
wiskott-aldrich syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
This symptom has already been validated