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Uterine cervical sarcoidosis identified on pap test: cytomorphologic findings and differential diagnosis.
[pleomorphic liposarcoma]
Sarcoidosis
is
a
multisystem
inflammatory
disease
of
uncertain
etiology
that
is
histopathologically
characterized
by
non-necrotizing
granulomas
.
It
typically
involves
the
lungs
and
lymph
nodes
,
but
has
been
reported
in
many
other
organ
systems
as
well
.
Sarcoidosis
involving
the
female
genital
tract
,
the
uterus
in
particular
,
is
a
rare
event
with
isolated
accounts
in
the
medical
literature
.
We
present
a
rare
occurrence
of
cervical
sarcoidosis
in
a
Pap
test
of
a
31
-
year
-old
woman
with
a
history
of
biopsy-proven
mediastinal
lymph
node
sarcoidosis
and
mediastinal
pleomorphic
liposarcoma
with
status
post
chemotherapy
.
The
Surepath
smear
showed
crowded
cellular
groups
with
abundant
epithelioid
histiocytes
and
lymphocytes
consistent
with
granulomatous
inflammation
.
No
granular
necrotic
debris
or
polarizable
foreign
body
material
was
identified
.
There
were
no
microorganisms
present
.
The
cytomorphologic
features
and
differential
diagnoses
are
discussed
.
Uterine
cervical
sarcoidosis
,
although
rare
,
can
be
an
overlooked
cause
of
non-necrotizing
granulomatous
inflammation
in
a
cervical
Pap
test
.
Sarcoidosis
should
be
a
diagnosis
of
exclusion
;
other
common
conditions
with
similar
morphologic
presentation
such
as
non-necrotizing
tuberculosis
,
foreign
body-related
granulomatous
inflammation
,
and
neoplastic
/
chemotherapy-related
sarcomatoid
reaction
need
to
be
excluded
in
conjunction
with
the
patient
's
clinical
history
.