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Pre-operative irradiation for retroperitoneal liposarcoma: results of a pilot study.
[dedifferentiated liposarcoma]
The
aim
of
this
study
was
to
evaluate
toxicity
and
benefit
of
an
original
method
of
preoperative
irradiation
combined
with
adequate
surgery
in
the
treatment
of
retroperitoneal
liposarcoma
.
Instead
of
irradiating
the
whole
tumor
volume
,
50
Gy
in
25
fractions
was
delivered
to
the
posterior
part
of
the
tumor
and
the
contact
zone
with
the
postero-
lateral
abdominal
wall
only
.
Between
mid-
2000
and
end
of
2011
,
29
patients
were
included
in
this
study
,
22
with
a
primary
tumor
,
7
with
a
first
local
recurrence
.
The
results
obtained
were
compared
with
a
well-matched
control
group
operated
on
by
the
same
surgeon
during
the
same
period
.
This
therapy
was
well
tolerated
by
all
included
patients
and
no
difference
in
toxicity
was
found
between
pilot
and
control
group
.
With
a
median
follow-up
of
84
months
the
oncological
results
were
similar
in
both
groups
with
a
5
y
disease
specific
survival
of
79
and
81
%
(
p
:
0
.
61
)
.
However
a
very
significant
difference
was
found
according
to
histotype
:
five
year
disease
specific
survival
was
84
%
(
CI
66
-
93
)
for
the
well-
differentiated
and
only
35
%
(
CI
20
-
51
)
for
the
dedifferentiated
liposarcoma
(
p
<
0
.
0001
)
.
This
form
of
combined
treatment
is
well
tolerated
but
superiority
could
not
be
demonstrated
.
Our
experience
clarifies
some
of
the
difficulties
facing
a
randomized
clinical
trial
on
this
topic
.
