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The association between miR-499a polymorphism and oral squamous cell carcinoma progression.
[oral submucous fibrosis]
To
investigate
the
association
of
miR-
499
a
genetic
polymorphism
with
the
risk
of
oral
leukoplakia
,
oral
submucous
fibrosis
(
OSF
)
,
oral
squamous
cell
carcinoma
(
OSCC
)
,
and
clinicopathological
outcomes
of
OSCC
.
T
he
genotyping
of
miR-
499
a
T
>
C
(
rs
3746444
)
using
TagMan
assay
was
conducted
in
two
case-control
studies
of
1549
subjects
.
miR-
499
a-
5
p
and
miR-
499
a-
3
p
were
assayed
using
stem-loop
RT-PCR
for
63
paired
OSCC
and
adjacent
normal
tissues
.
T
/
C
+
C
/
C
genotypes
[
adjusted
odds
ratio
(
AOR
)
1
.
84
,
P
Â
=
Â
0
.
032
]
and
C
allelic
type
(
AOR
1
.
91
,
P
Â
=
Â
0
.
007
)
at
miR-
499
a
T
>
C
were
associated
with
an
increased
risk
of
BQ-related
OSF
as
compared
to
those
with
T
/
T
genotype
or
T
allelic
type
,
respectively
.
Conversely
,
T
/
C
+
C
/
C
genotypes
and
C
allelic
type
decreased
the
risk
of
OSCC
,
especially
for
non-
BQ-related
OSCC
(
for
genotype
:
AOR
0
.
49
,
P
Â
=
Â
0
.
010
;
for
allelic
type
:
AOR
0
.
50
,
P
Â
=
Â
0
.
007
)
.
Additionally
,
downregulation
of
miR-
499
a-
5
p
was
found
in
OSCC
tissues
(
P
Â
=
Â
0
.
001
)
and
correlated
with
the
TT
genotype
(
P
Â
=
Â
0
.
001
)
.
The
T
/
C
+
C
/
C
genotypes
of
MiR-
499
a
may
contribute
to
an
increased
risk
of
BQ-related
OSF
,
but
a
decreased
risk
of
OSCC
.
miR-
499
a
T
>
C
influences
the
expression
levels
of
miR-
499
a-
5
p
during
the
tumorigenesis
of
OSCC
.
Diseases
Validation
Diseases presenting
"decreased risk of oscc. mir-499"
symptom
oral submucous fibrosis
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