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Does maternal drug ingestion cause megacystis microcolon intestinal hypoperistalsis syndrome? III. Ethanol trial.
[megacystis-microcolon-intestinal hypoperistalsis syndrome]
Megacystis
Microcolon
Intestinal
Hypoperistalsis
Syndrome
(
MMIHS
)
is
a
congenital
disease
,
and
the
etiology
of
the
disease
is
unclear
.
It
is
speculated
that
maternal
ingestion
of
some
drugs
during
pregnancy
may
be
an
etiologic
factor
.
In
this
study
we
aimed
to
investigate
the
effect
of
maternal
ingestion
of
ethanol
on
the
fetal
bladder
and
colon
in
pregnant
rats
.
We
separated
animals
into
an
ethanol
group
including
30
rats
and
a
control
group
with
14
rats
.
Nothing
was
given
to
the
control
group
during
pregnancy
.
Orogastrically
2
cc
/
day
30
%
ethanol
was
given
to
the
study
group
from
the
6
th
to
12
th
day
of
pregnancy
.
All
of
them
were
sacrificed
on
the
20
th
day
of
pregnancy
.
Histopathological
examination
of
the
fetal
colon
and
bladder
was
performed
.
In
the
ethanol
group
a
significant
decrease
in
the
colon
and
bladder
diameter
,
a
significant
decrease
in
the
thickness
of
the
colon
and
bladder
wall
,
an
increase
in
vacuolar
degeneration
in
the
muscles
of
the
bladder
wall
,
an
increase
in
connective
tissue
proliferation
among
the
muscles
of
the
bladder
,
a
significant
decrease
in
the
number
of
ganglion
cells
in
the
myenteric
plexus
of
the
colon
and
a
significant
decrease
in
the
thickness
of
the
bladder
tunica
muscularis
were
determined
.
In
our
rat
model
we
found
histological
structural
changes
in
the
rats
'
colon
and
bladder
wall
similar
to
a
pathological
finding
found
in
some
of
the
MMIHS
patients
'
bowel
and
bladder
as
a
result
of
using
ethanol
on
the
6
th
-
12
th
days
of
pregnancy
.