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[Role of septin cytoskeleton in dopaminergic neurotransmission and neurodegeneration].
[neuralgic amyotrophy]
Cytoskeletal
polymers
play
pleiotropic
roles
in
neuroglial
morphogenesis
,
intracellular
transport
,
organization
of
pre-
and
post-synaptic
scaffolds
,
etc
.
Thus
,
neuroglial
dysfunction
and
degeneration
are
often
accompanied
by
abnormalities
in
microtubules
,
actin
and
/
or
intermediate
filament
systems
.
Although
our
understanding
of
an
unconventional
cytoskeletal
system
composed
of
the
septin
family
of
GTP-binding
proteins
is
far
behind
,
recent
studies
have
been
revealing
that
qualitative
and
/
or
quantitative
abnormalities
of
septins
are
also
associated
with
neurodegenerative
disorders
including
hereditary
neuralgic
amyotrophy
,
Parkinson
disease
,
schizophrenia
and
bipolar
disorder
.
A
better
understanding
of
the
physiological
and
pathophysiological
roles
of
the
septin
system
should
help
develop
useful
biomarkers
and
therapeutic
strategies
for
these
diseases
.
