Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
A real-time fMRI-based spelling device immediately enabling robust motor-independent communication.
[locked-in syndrome]
Human
communication
entirely
depends
on
the
functional
integrity
of
the
neuromuscular
system
.
This
is
devastatingly
illustrated
in
clinical
conditions
such
as
the
so
-called
locked-
in
syndrome
(
LIS
)
,
in
which
severely
motor
-disabled
patients
become
incapable
to
communicate
naturally--while
being
fully
conscious
and
awake
.
For
the
last
20
years
,
research
on
motor
-independent
communication
has
focused
on
developing
brain
-computer
interfaces
(
BCIs
)
implementing
neuroelectric
signals
for
communication
(
e
.
g
.
,
[
2
-
7
]
)
,
and
BCIs
based
on
electroencephalography
(
EEG
)
have
already
been
applied
successfully
to
concerned
patients
.
However
,
not
all
patients
achieve
proficiency
in
EEG-based
BCI
control
.
Thus
,
more
recently
,
hemodynamic
brain
signals
have
also
been
explored
for
BCI
purposes
.
Here
,
we
introduce
the
first
spelling
device
based
on
fMRI
.
By
exploiting
spatiotemporal
characteristics
of
hemodynamic
responses
,
evoked
by
performing
differently
timed
mental
imagery
tasks
,
our
novel
letter
encoding
technique
allows
translating
any
freely
chosen
answer
(
letter-
by
-letter
)
into
reliable
and
differentiable
single
-trial
fMRI
signals
.
Most
importantly
,
automated
letter
decoding
in
real
time
enables
back-and-forth
communication
within
a
single
scanning
session
.
Because
the
suggested
spelling
device
requires
only
little
effort
and
pretraining
,
it
is
immediately
operational
and
possesses
high
potential
for
clinical
applications
,
both
in
terms
of
diagnostics
and
establishing
short
-term
communication
with
nonresponsive
and
severely
motor
-
impaired
patients
.
Diseases
Validation
Diseases presenting
"so-called locked-in syndrome"
symptom
locked-in syndrome
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