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Relationship of angiogenic and apoptotic activities in soft-tissue sarcoma.
[liposarcoma]
Angiogenesis
and
apoptosis
play
an
essential
role
in
tumor
development
and
progression
.
Previous
studies
on
apoptosis
and
angiogenesis
of
soft
-tissue
sarcoma
(
STS
)
were
done
separately
.
This
is
the
first
study
of
the
relationship
between
apoptotic
and
angiogenic
activity
.
Correlation
of
expression
of
anti-apoptotic
protein
(
Bcl-
2
)
and
pro-apoptotic
protein
(
Bax
)
in
the
tumor
cells
(
TCs
)
with
their
expression
in
endothelial
cell
(
EC
)
of
the
tumor
blood
vessels
in
STS
were
also
carried
out
.
101
cases
of
STS
;
consisting
liposarcoma
,
malignant
fibrous
histiocytoma
,
synovial
sarcoma
,
fibrosarcoma
,
leiomyosarcoma
,
rhabdomyosarcoma
and
malignant
peripheral
nerve
sheath
tumor
;
were
collected
and
immunohistochemical
reaction
of
vascular
endothelial
growth
factor
(
VEGF
)
,
Bcl-
2
and
Bax
were
examined
.
Higher
Bax
expression
in
TCs
(
54
.
5
%
)
was
seen
compared
to
Bcl-
2
expression
(
44
.
6
%
)
.
There
was
a
significant
association
between
Bcl-
2
and
Bax
in
TCs
with
ECs
.
Significant
association
was
also
seen
between
histological
types
of
STS
with
Bcl-
2
expression
;
however
not
with
Bax
expression
.
There
was
an
association
between
VEGF
and
Bax
with
high
VEGF
expression
and
weak
Bax
expression
.
However
,
VEGF
expression
was
not
associated
with
Bcl-
2
expression
and
histological
types
.
This
study
supports
the
role
of
ECs
of
tumor
blood
vessels
and
apoptosis
of
TCs
in
tumor
management
.
Increased
angiogenesis
may
inhibit
apoptosis
of
TCs
and
lead
to
tumor
growth
.
Therefore
,
inhibition
of
ECs
survival
or
activation
of
ECs
death
is
promising
prospect
for
tumor
therapy
.
Immunohistochemical
antibodies
in
this
study
might
be
potential
useful
marker
for
the
prognosis
of
STS
.
Diseases
Validation
Diseases presenting
"growth factor"
symptom
22q11.2 deletion syndrome
achondroplasia
adrenal incidentaloma
aniridia
cadasil
cholangiocarcinoma
coats disease
dedifferentiated liposarcoma
dentin dysplasia
dentinogenesis imperfecta
dystrophic epidermolysis bullosa
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
holt-oram syndrome
inclusion body myositis
kallmann syndrome
krabbe disease
liposarcoma
lymphangioleiomyomatosis
oculocutaneous albinism
oral submucous fibrosis
pleomorphic liposarcoma
primary effusion lymphoma
primary hyperoxaluria type 1
severe combined immunodeficiency
systemic capillary leak syndrome
von hippel-lindau disease
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
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