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Cytoplasmic 5'-nucleotidase autoantibodies in inclusion body myositis: Isotypes and diagnostic utility.
[inclusion body myositis]
Recent
studies
have
identified
circulating
immunoglobulin
(
Ig
)
G
autoantibodies
against
cytoplasmic
5
'
-
nucleotidase
1
A
(
cN
1
A
;
NT
5
C
1
A
)
in
patients
with
inclusion
body
myositis
(
IBM
)
,
whose
detection
provides
for
an
IBM
blood
diagnostic
test
.
Whether
or
not
anti-c
N
1
A
autoantibody
isotypes
other
than
IgG
are
present
in
IBM
has
not
previously
been
reported
.
Plasma
and
serum
samples
from
205
patients
(
50
with
and
155
without
IBM
)
were
studied
for
the
presence
of
IgM
and
IgA
,
in
addition
to
IgG
,
anti-c
N
1
A
autoantibodies
using
immunoblots
and
enzyme-linked
immunoassays
(
ELISAs
)
.
IgM
,
IgA
,
and
IgG
anti-c
N
1
A
autoantibodies
were
detected
by
ELISA
with
similar
sensitivities
(
49
-
53
%
)
and
specificities
(
94
-
96
%
)
,
but
with
differing
patterns
of
autoantibody
isotype
presence
.
Combination
assays
of
all
3
autoantibody
levels
improved
diagnostic
sensitivity
to
76
%
.
In
addition
to
previously
recognized
IgG
anti-c
N
1
A
autoantibodies
,
IBM
patients
have
circulating
IgM
and
IgA
anti-c
N
1
A
autoantibodies
.
Differing
patterns
of
these
isotypes
may
be
present
and
useful
for
diagnosis
.
Diseases
Validation
Diseases presenting
"myositis"
symptom
focal myositis
inclusion body myositis
malignant atrophic papulosis
pyomyositis
systemic capillary leak syndrome
This symptom has already been validated
