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High level of CDK4 amplification is a poor prognostic factor in well-differentiated and dedifferentiated liposarcoma.
[dedifferentiated liposarcoma]
The
amplification
of
MDM
2
and
CDK
4
is
the
main
molecular
feature
of
well-differentiated
liposarcomas
(
WDLS
)
and
dedifferentiated
liposarcomas
(
DDLS
)
.
Although
the
diagnostic
usefulness
of
this
molecular
characteristic
in
liposarcomas
has
been
investigated
,
its
prognostic
utility
of
quantitative
gene
level
has
not
been
explored
.
The
aim
of
this
study
was
to
assess
the
prognostic
significance
of
level
of
CDK
4
amplification
in
MDM
2
-
amplified
WDLS
/
DDLS
.
MDM
2
amplification
in
liposarcomas
was
confirmed
by
fluorescence
in
situ
hybridization
.
The
copy
number
of
MDM
2
and
CDK
4
was
further
determined
by
quantitative
PCR
(
qPCR
)
and
multiplex
ligation-dependent
probe
amplification
.
Among
56
MDM
2
-
amplified
liposarcomas
,
30
cases
were
assigned
as
WDLS
,
and
26
as
DDLS
.
When
liposarcomas
were
classified
by
qPCR-determined
CDK
4
amplification
levels
,
the
high
-
CDK
4
group
showed
significantly
poorer
progression
free
survival
(
P
=
0
.
001
)
and
disease
specific
survival
(
P
=
0
.
033
)
than
the
low
-
CDK
4
group
.
However
,
MDM
2
amplification
level
did
not
show
prognostic
significance
.
In
WDLS
/
DDLS
,
the
level
of
CDK
4
amplification
was
useful
for
prognosis
prediction
and
precise
stratification
of
patients
for
targeted
therapy
.