Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
The role of interleukin-17 in immune-mediated inflammatory myopathies and possible therapeutic implications.
[inclusion body myositis]
The
idiopathic
inflammatory
myopathies
are
a
heterogeneous
group
of
autoimmune
muscle
disorders
with
distinct
clinical
and
pathological
features
and
underlying
immunopathogenic
mechanisms
.
Traditionally
,
CD
4
(
+
)
Th
1
cells
or
CD
8
(
+
)
cytotoxic
effector
T
cells
and
type
I
/
II
interferons
have
been
primarily
implicated
in
the
pathogenesis
of
the
inflammatory
myopathies
.
The
presence
of
IL
-
17
A
producing
cells
in
the
inflamed
muscle
tissue
of
myositis
patients
and
the
results
of
in
vitro
studies
suggest
that
IL
-
17
A
and
the
Th
17
pathway
may
also
have
a
key
role
in
these
diseases
.
The
contribution
of
IL
-
17
A
to
other
chronic
inflammatory
and
autoimmune
diseases
has
been
well
established
and
clinical
trials
of
IL
-
17
A
inhibitors
are
now
at
an
advanced
stage
.
However
the
precise
role
of
IL
-
17
A
in
the
various
forms
of
myositis
and
the
potential
for
therapeutic
targeting
is
currently
unknown
and
warrants
further
investigation
.
Diseases
Validation
Diseases presenting
"inflammatory myopathies"
symptom
familial mediterranean fever
focal myositis
inclusion body myositis
pyomyositis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom
