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Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma.
[hodgkin lymphoma, classical]
Cannabinoid
receptor
1
(
CB
1
)
is
expressed
in
certain
types
of
malignancies
.
An
analysis
of
CB
1
expression
and
function
in
Hodgkin
lymphoma
(
HL
)
,
one
of
the
most
frequent
lymphomas
,
was
not
performed
to
date
.
We
examined
the
distribution
of
CB
1
protein
in
primary
cases
of
HL
.
Using
lymphoma
derived
cell
lines
,
the
role
of
CB
1
signaling
on
cell
survival
was
investigated
.
A
predominant
expression
of
CB
1
was
found
in
Hodgkin-
Reed
-
Sternberg
cells
in
a
vast
majority
of
classical
HL
cases
.
The
HL
cell
lines
L
428
,
L
540
and
KM-H
2
showed
strong
CB
1
-
abundance
and
displayed
a
dose-dependent
decline
of
viability
under
CB
1
inhibition
with
AM
251
.
Further
,
application
of
AM
251
led
to
decrease
of
constitutively
active
NFκB
/
p
65
,
a
crucial
survival
factor
of
HRS-cells
,
and
was
followed
by
elevation
of
apoptotic
markers
in
HL
cells
.
T
he
present
study
identifies
CB
1
as
a
feature
of
HL
,
which
might
serve
as
a
potential
selective
target
in
the
treatment
of
Hodgkin
lymphoma
.
