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The prognostic value of interim positron emission tomography scan in patients with classical Hodgkin lymphoma.
[hodgkin lymphoma, classical]
The
prognostic
value
of
interim
positron
emission
tomography
(
PET
)
was
evaluated
after
2
cycles
of
doxorubicin
,
bleomycin
,
vinblastin
and
dacarbazine
in
classical
Hodgkin
lymphoma
patients
(
n
Â
=
Â
229
)
,
based
on
Deauville
criteria
.
In
early
stage
non-bulky
disease
,
bulky
stage
II
disease
,
advanced
stage
low
International
Prognostic
Score
(
IPS
≤
2
)
and
advanced
stage
(
IPS
≥
3
)
,
3
-
year
progression-free
survival
rates
in
PET
2
-
negative
vs
.
PET
2
-
positive
groups
were
95
·
9
%
vs
.
76
·
9
%
(
P
Â
<
Â
0
·
0018
)
,
83
·
3
%
vs
.
20
·
0
%
(
P
Â
=
Â
0
·
017
)
,
77
·
0
%
vs
.
30
·
0
%
(
P
Â
<
Â
0
·
001
)
and
71
·
0
%
vs
.
44
·
4
%
(
P
Â
=
Â
0
·
155
)
,
respectively
.
The
outcome
after
positive
PET
2
was
better
than
previously
reported
.
The
results
from
non-randomized
studies
of
PET
2
-
guided
therapy
would
be
valuable
with
careful
interpretation
.
