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Hodgkin lymphoma incidence in California Hispanics: influence of nativity and tumor Epstein-Barr virus.
[hodgkin lymphoma, classical]
For
classical
Hodgkin
lymphoma
(
HL
)
,
migrant
studies
could
elucidate
contributions
of
environmental
factors
(
including
Epstein-
Barr
virus
(
EBV
)
)
to
the
lower
rates
in
non-whites
.
Given
the
well-described
etiologic
complexity
of
HL
,
this
research
requires
a
large
,
immigrant
population
,
such
as
California
Hispanics
.
With
1988
-
2004
California
Cancer
Registry
data
(
2
,
595
Hispanic
,
8
,
637
white
HL
cases
)
and
tumor
cell
EBV
status
on
a
subset
(
218
Hispanics
,
656
whites
)
,
we
calculated
ethnicity-
and
nativity-
specific
HL
incidence
rates
simultaneously
by
age
,
sex
,
and
histologic
subtype
,
and
tumor
cell
EBV
prevalence
.
Compared
with
white
rates
,
Hispanic
HL
rates
were
lower
overall
(
70
%
)
and
for
nodular
sclerosis
HL
,
particularly
among
young
adults
(
60
-
65
%
for
females
)
.
However
,
they
were
higher
among
children
(
200
%
)
and
older
adults
,
and
for
mixed
cellularity
HL
.
Compared
with
rates
in
foreign-born
Hispanics
,
rates
in
US
-born
Hispanics
were
higher
among
young
adults
(
>
threefold
in
females
)
,
lower
for
children
and
adults
over
age
70
,
and
consistently
intermediate
compared
with
rates
in
whites
.
EBV
tumor
prevalence
was
67
,
32
,
and
23
%
among
foreign-born
Hispanics
,
US
-born
Hispanics
,
and
whites
,
respectively
,
although
with
variation
by
age
,
sex
,
and
histology
.
Findings
strongly
implicate
environmental
influences
,
such
as
nativity-related
sociodemographic
differences
,
on
HL
occurrence
.
In
addition
,
lower
young
adult
rates
and
higher
EBV
prevalence
in
US
-born
Hispanics
than
in
whites
raise
questions
about
the
duration
/
extent
of
environmental
change
for
affecting
HL
rates
and
also
point
to
ethnic
differences
in
genetic
susceptibility
.
Lesser
variation
in
mixed
cellularity
HL
rates
and
greater
variation
in
rates
for
females
across
groups
suggest
less
modifiable
factors
interacting
with
environmental
influences
.
Diseases
Validation
Diseases presenting
"tumor cell"
symptom
hodgkin lymphoma, classical
von hippel-lindau disease
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