Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Estimation of serum and salivary immunoglobulin G and immunoglobulin A in oral pre-cancer: A study in oral submucous fibrosis and oral lichen planus.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSMF
)
and
oral
lichen
planus
(
OLP
)
are
two
frequently
reported
,
potentially
malignant
disorders
with
multifactorial
etiologies
and
ambiguous
pathogenesis
.
An
immunological
pathogenesis
has
been
hypothesized
as
a
causative
factor
for
both
.
The
present
study
aims
to
evaluate
the
role
of
serum
and
salivary
immunoglobulin
G
(
IgG
)
and
immunoglobulin
A
(
IgA
)
in
both
these
conditions
,
by
their
quantitative
estimation
.
Saliva
and
serum
samples
were
collected
from
30
patients
,
clinically
diagnosed
and
histopathologically
confirmed
with
OSMF
,
30
with
OLP
and
30
age
and
sex
matched
controls
.
The
levels
of
IgG
and
IgA
were
estimated
by
nephelometry
.
The
mean
values
of
serum
IgG
were
marginally
higher
in
both
OSMF
and
OLP
groups
compared
to
the
controls
but
this
difference
was
not
significant
and
the
mean
values
of
serum
immunoglobulin
A
were
marginally
decreased
in
both
the
study
groups
compared
to
the
controls
but
this
difference
was
also
not
significant
.
Inconclusively
low
levels
of
salivary
IgG
and
IgA
were
obtained
in
the
three
groups
.
The
present
study
suggests
an
insignificant
association
of
these
immunoglobulins
in
the
pathogenesis
of
both
these
diseases
.
