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A random Abstract
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Primary mediastinal large B-cell lymphoma.
[hodgkin lymphoma, classical]
Primary
mediastinal
B-
cell
lymphoma
(
PMBCL
)
is
a
relatively
rare
lymphoma
subtype
affecting
mainly
young
adults
.
Its
molecular
signature
and
clinical
features
resemble
classical
Hodgkin
lymphoma
.
The
optimal
chemotherapy
for
this
lymphoma
subtype
has
not
been
established
.
The
addition
of
rituximab
to
anthracycline
based
chemotherapy
improved
response
rates
and
survival
.
Many
centers
use
R-CHOP
as
standard
treatment
,
but
the
role
of
the
intensified
regimens
and
consolidation
radiotherapy
has
to
be
clarified
.
Recent
data
coming
from
retrospective
analyses
and
an
ongoing
prospective
study
addressing
the
problem
of
consolidation
radiotherapy
will
help
to
better
identify
risk
groups
and
apply
risk-adapted
and
effective
treatment
strategies
.
The
latest
research
has
helped
to
understand
molecular
mechanisms
of
PMBCL
pathogenesis
and
indicated
targets
of
directed
therapy
for
the
future
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated