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[Soluble vascular adhesion-1 molecule in Sneddon syndrome: clinical and prognostic value].
[sneddon syndrome]
Clinical
significance
of
a
soluble
vascular
adhesion-
1
molecule
(
pVCAM-
1
)
in
Sneddon
's
syndrome
(
SS
)
was
studied
in
48
SS
patients
by
examination
of
serum
pVCAM-
1
level
using
enzyme
immunoassay
(
R
&
D
,
USA
)
.
High
serum
concentration
of
pVCAM-
1
registered
in
62
.
6
%
of
SS
patients
was
associated
with
extracerebral
thromboses
,
not
with
severity
of
cerebral
vessel
damage
.
Lethal
outcomes
for
2
years
of
follow-up
occurred
more
frequently
in
patients
with
a
high
basal
level
of
pVCAM-
1
than
in
patients
with
normal
level
.
Thus
,
development
of
the
pathological
process
in
SS
is
associated
with
elevated
concentration
of
serum
pVCAM-
1
and
may
serve
an
additional
laboratory
indicator
of
developing
extrabrain
thrombotic
disorders
and
marker
of
unfavourable
prognosis
.
