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Anaplastic large cell lymphoma: features presenting diagnostic challenges.
[hodgkin lymphoma, classical]
Anaplastic
large
cell
lymphoma
has
histopathologic
features
that
necessitate
a
broad
differential
diagnosis
.
Diagnostic
considerations
include
carcinoma
,
melanoma
,
and
hematopoietic
malignancies
,
including
diffuse
large
B-
cell
lymphoma
,
classical
Hodgkin
lymphoma
,
myeloid
sarcoma
,
and
peripheral
T-
cell
lymphoma
,
not
otherwise
specified
.
Unusual
features
can
include
subtle
sinusoidal
involvement
,
histiocytic
morphology
,
cytokeratin
expression
,
CD
15
expression
,
and
variant
patterns
of
anaplastic
lymphoma
kinase
expression
.
Cases
with
unusual
morphologic
or
immunohistochemical
findings
will
be
presented
to
highlight
the
complexity
encountered
in
practice
.
Diseases
Validation
Diseases presenting
"large cell lymphoma"
symptom
focal myositis
hodgkin lymphoma, classical
systemic capillary leak syndrome
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