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BOB.1-positive Classical Hodgkin's Lymphoma Carries Hypermethylation of Its Promoter as Epigenetic Marker of Gene-silencing Memory.
[hodgkin lymphoma, classical]
Analysis
of
archival
formalin-fixed
,
paraffin-embedded
(
FFPE
)
pathological
specimens
of
three
case
of
Epstein-
Barr
virus
(
EBV
)
-
positive
diffuse
large
B-
cell
lymphoma
(
DLBCL
)
and
three
cases
of
classical
Hodgkin
lymphoma
(
CHL
)
revealed
that
hypermethylation
of
the
BOB
.
1
gene
promoter
was
exclusively
observed
in
CHL
.
A
discrepancy
was
observed
,
however
,
between
the
methylation
status
of
the
BOB
.
1
gene
promoter
and
its
expression
in
the
EBV-
positive
mixed
cellular
CHL
(
MCCHL
)
.
Since
MCCHL
lacks
the
typical
B-
cell
phenotype
even
in
the
presence
of
abundant
BOB
.
1
transcription
factors
,
functional
activity
of
BOB
.
1
may
be
lost
or
reduced
by
a
mechanism
other
than
epigenetic
gene
silencing
.
When
some
tumor
-suppressor
gene
products
have
lost
their
biological
function
,
impact
or
significance
of
derepression
of
such
genes
may
be
little
.
Therefore
,
when
interpreting
immunohistochemical
results
for
diagnostic
or
research
purposes
,
it
must
be
borne
in
mind
that
apparent
positive
immunostaining
can
merely
be
the
result
of
chromatin
remodeling
and
that
such
transient
expression
often
has
little
functional
significance
.
Any
apparent
positive
immunohistochemical
result
needs
to
be
interpreted
carefully
with
the
help
of
the
hypermethylation
status
as
a
molecular
marker
of
gene
silencing
memory
.
Diseases
Validation
Diseases presenting
"apparent positive immunohistochemical result"
symptom
hodgkin lymphoma, classical
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