Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells.
[hereditary cerebral hemorrhage with amyloidosis]
The
amyloid
beta
-protein
(
A
beta
)
pathologically
accumulates
in
cerebral
vascular
and
senile
plaque
deposits
in
the
brains
of
patients
with
Alzheimer
's
disease
(
AD
)
and
related
disorders
including
hereditary
cerebral
hemorrhage
with
amyloidosis
Dutch
type
(
HCHWA-D
)
.
The
cerebrovascular
deposits
are
accompanied
by
degeneration
and
eventual
loss
of
smooth
muscle
cells
in
cerebral
vessel
wall
.
Similarly
,
we
have
shown
that
pathogenic
forms
of
A
beta
cause
cell
death
in
cultured
human
cerebrovascular
smooth
muscle
(
HCSM
)
cells
in
vitro
.
Here
we
show
that
pathogenic
A
beta
induces
a
number
of
structural
changes
in
HCSM
cells
including
shrinkage
of
cell
bodies
,
retraction
of
processes
,
disruption
of
the
intracellular
actin
network
,
and
nuclear
condensation
and
fragmentation
.
These
changes
were
accompanied
by
a
number
of
biochemical
alterations
in
the
cells
shown
by
in
situ
end
labeling
of
nuclear
DNA
,
proteolytic
breakdown
of
smooth
muscle
cell
a
actin
,
and
proteolytic
activation
of
the
proteinase
caspase
3
.
Together
,
these
characteristics
are
consistent
with
an
apoptotic
mechanism
of
cell
death
in
HCSM
cells
in
response
to
pathogenic
A
beta
.
Diseases
Validation
Diseases presenting
"muscle cell"
symptom
cadasil
congenital diaphragmatic hernia
hereditary cerebral hemorrhage with amyloidosis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom