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Expression of klotho and β-catenin in esophageal squamous cell carcinoma, and their clinicopathological and prognostic significance.
[esophageal squamous cell carcinoma]
Esophageal
carcinoma
is
one
of
the
most
common
types
of
cancers
in
the
world
;
the
molecular
mechanism
underlying
its
tumorigenesis
is
still
not
well
understood
.
This
study
was
aimed
at
investigating
the
expression
of
klotho
and
β-catenin
in
patients
with
esophageal
squamous
cell
carcinoma
(
ESCC
)
and
analyzing
their
association
with
clinicopathological
variables
and
their
effects
on
prognosis
.
The
expression
patterns
of
klotho
and
β-catenin
were
determined
by
tissue
microarray
and
immunohistochemical
technique
in
ESCC
and
normal
tissues
,
and
their
correlations
with
clinicopathological
characteristics
were
investigated
using
univariate
and
multivariate
analysis
.
The
serum
klotho
levels
in
40
ESCC
patients
and
controls
were
measured
by
sandwich
enzyme-linked
immunosorbent
assay
system
(
ELISA
)
.
The
expression
level
of
klotho
was
significantly
lower
in
ESCC
than
in
the
adjacent
noncancerous
tissues
(
30
vs
.
50
%
,
P
<
0
.
000
)
,
and
the
protein
level
was
negative
correlated
with
clinical
staging
,
histological
grade
,
lymph
node
metastasis
,
and
invasion
depth
(
P
<
0
.
05
)
.
Whereas
,
the
expression
of
β-catenin
was
much
higher
in
ESCC
than
their
corresponding
normal
mucosa
tissues
(
78
.
3
vs
.
11
.
5
%
,
P
<
0
.
000
)
,
and
the
level
of
protein
correlated
only
with
histological
grade
and
invasion
depth
(
P
<
0
.
05
)
.
Correlation
analysis
showed
the
expression
level
of
klotho
inversely
correlated
with
that
of
β-catenin
(
r
=
-
0
.
214
,
P
<
0
.
01
)
.
Patients
with
klotho
-
positive
tumors
had
longer
survival
than
those
with
klotho
-negative
tumors
(
P
<
0
.
01
)
.
Cox
proportional
hazards
model
analysis
demonstrated
that
positive
expression
of
klotho
was
an
important
factor
indicating
good
prognosis
(
hazard
ratio
,
0
.
371
;
95
%
confidence
interval
,
0
.
201
-
0
.
685
;
P
<
0
.
01
)
.
ELISA
showed
that
the
level
of
serum
klotho
was
markedly
higher
(
461
.
50
±
43
.
30
 
pg
/
mL
)
than
control
group
(
239
.
37
±
20
.
65
 
pg
/
mL
)
(
P
<
0
.
001
)
.
Receiver
operating
characteristic
analysis
gave
a
cut-off
value
of
327
.
031
of
serum
klotho
with
a
sensitivity
of
81
.
3
%
and
specificity
of
81
.
2
%
(
P
<
0
.
000
)
.
Our
present
study
demonstrated
for
the
first
time
that
klotho
might
be
a
novel
biomarker
candidate
for
predicting
progression
and
prognosis
in
patients
with
ESCC
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated
