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Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
Esophageal
squamous
cell
carcinoma
(
ESCC
)
is
one
of
the
prevalent
and
deadly
cancers
worldwide
,
especially
in
Eastern
Asia
.
The
prognosis
of
ESCC
remains
poor
;
thus
,
it
is
still
necessary
to
further
dissect
the
underlying
mechanisms
and
explore
therapeutic
targets
of
ESCC
.
Recent
studies
show
that
long
noncoding
RNAs
(
lncRNAs
)
have
critical
roles
in
diverse
biological
processes
,
including
tumorigenesis
.
Some
lncRNAs
,
such
as
HOTAIR
and
POU
3
F
3
,
were
reported
to
play
important
roles
in
ESCC
.
Here
,
we
characterized
the
expression
profile
of
taurine-upregulated
gene
1
(
TUG
1
)
,
a
lncRNA
recruiting
and
binding
to
polycomb
repressive
complex
2
(
PRC
2
)
,
in
ESCC
.
In
a
cohort
of
62
patients
,
TUG
1
was
significantly
overexpressed
in
ESCC
tissues
compared
with
paired
adjacent
normal
tissues
,
and
high
expression
level
of
TUG
1
was
associated
with
family
history
and
upper
segment
of
esophageal
cancer
(
p
 
<
 
0
.
05
)
.
Further
,
in
vitro
silencing
TUG
1
via
siRNA
inhibited
the
proliferation
and
migration
of
ESCC
cells
and
blocked
the
progression
of
cell
cycle
.
Therefore
,
our
study
indicates
that
TUG
1
promotes
proliferation
and
migration
of
ESCC
cells
and
is
a
potential
oncogene
of
ESCC
.
Diseases
Validation
Diseases presenting
"including tumorigenesis"
symptom
esophageal squamous cell carcinoma
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