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Association of p53 expression with prognosis in patients with esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
It
has
been
well
accepted
that
p
53
overexpression
is
associated
with
advanced
stages
of
cancer
.
However
,
the
prognostic
role
of
p
53
overexpression
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
remains
unclear
.
To
investigate
the
prognostic
role
of
p
53
overexpression
in
patients
with
ESCC
,
a
retrospective
cohort
study
of
136
ESCC
patients
was
carried
out
.
The
expression
of
p
53
protein
in
tumor
tissues
was
investigated
immunohistochemically
.
Positive
expression
of
p
53
protein
was
detected
in
57
ESCC
patients
(
41
.
9
%
)
.
The
p
53
overexpression
was
associated
with
smoking
(
P
<
0
.
001
)
,
tumor
differentiation
(
P
<
0
.
001
)
,
and
tumor
size
(
P
<
0
.
001
)
.
In
the
Kaplan-
Meier
analysis
,
patients
with
p
53
overexpression
had
significantly
shorter
overall
survival
than
those
patients
with
negative
p
53
expression
(
log-rank
P
<
0
.
001
)
.
Multivariable
analysis
by
Cox
regression
model
further
showed
that
p
53
overexpression
was
a
significantly
independent
predictor
of
poorer
overall
survival
(
hazard
ratio
[
HR
]
=
1
.
91
;
95
%
confidence
interval
[
95
%
CI
]
1
.
03
-
3
.
54
,
P
=
0
.
04
)
.
Thus
,
p
53
overexpression
is
associated
with
poor
prognosis
in
patients
with
early
stage
esophageal
squamous
cell
carcinoma
,
and
it
's
a
significantly
independent
predictor
of
poorer
overall
survival
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated