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Evaluation of serum levels of carcinoembryonic antigen in allergic bronchopulmonary aspergillosis.
[allergic bronchopulmonary aspergillosis]
The
serum
level
of
carcinoembryonic
antigen
(
CEA
)
is
a
marker
of
malignant
disease
but
can
also
be
increased
in
benign
diseases
.
Patients
with
allergic
bronchopulmonary
aspergillosis
(
ABPA
)
have
bronchial
asthma
showing
a
wide
variety
of
radiological
findings
.
We
measured
serum
CEA
levels
in
patients
with
ABPA
and
evaluated
the
relationships
of
serum
CEA
levels
with
peripheral
blood
eosinophil
counts
,
total
blood
levels
of
immunoglobin
(
Ig
)
E
,
and
findings
of
computed
tomography
(
CT
)
in
ABPA
.
The
subjects
were
13
patients
(
6
men
and
7
women
aged
34
to
76
years
)
who
had
been
treated
for
ABPA
at
our
hospital
.
Serum
levels
of
CEA
,
peripheral
blood
eosinophil
counts
,
total
blood
IgE
levels
,
and
CT
findings
were
examined
before
and
after
treatment
with
prednisolone
.
Before
the
start
of
the
treatment
7
of
13
patients
had
serum
CEA
levels
higher
than
the
upper
limit
of
normal
.
The
serum
CEA
level
was
not
correlated
with
eosinophil
counts
or
total
IgE
values
.
Serum
CEA
levels
were
examined
after
treatment
in
9
patients
and
were
found
to
have
significantly
decreased
as
pulmonary
consolidation
improved
.
Furthermore
,
serum
CEA
levels
before
treatment
in
patients
with
pulmonary
consolidation
were
significantly
higher
than
those
in
patients
without
consolidation
.
Serum
CEA
levels
are
elevated
in
some
patients
with
ABPA
;
these
elevations
might
be
associated
with
consolidation
in
the
lung
.
Elevated
serum
CEA
levels
decrease
as
the
consolidation
decreases
after
treatment
.
The
elevation
of
serum
CEA
might
be
attributed
to
the
presence
of
local
inflammation
in
the
lung
.
