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Immunohistochemical evidence of association between ghrelin expression and tumor growth in esophageal carcinoma.
[esophageal carcinoma]
Ghrelin
,
an
orexigenic
peptide
,
is
primarily
produced
and
secreted
by
the
gastrointestinal
tract
.
As
far
as
we
are
aware
of
,
there
is
no
evidence
of
ghrelin
expression
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
.
Two
hundred
and
ten
patients
with
ESCC
who
underwent
surgical
resection
were
enrolled
in
this
study
.
We
immunohistochemically
investigated
ghrelin
expression
in
primary
ESCC
specimens
and
analyzed
the
relationship
with
clinicopathological
factors
.
High
ghrelin
expression
was
observed
in
61
patients
(
29
.
0
%
)
.
Depth
of
tumor
invasion
and
histological
differentiation
were
statistically
associated
with
ghrelin
expression
.
As
for
depth
of
tumor
invasion
,
the
deeper
it
was
,
the
higher
was
the
expression
of
ghrelin
.
Well-differentiated
tumors
had
a
significantly
higher
proportion
of
ghrelin-expressing
cells
than
other
types
.
Ghrelin
expression
correlated
with
tumor
depth
and
tumor
differentiation
,
suggesting
an
important
role
of
ghrelin
in
tumor
growth
in
ESCC
.
Diseases
Validation
Diseases presenting
"tumor growth"
symptom
adrenal incidentaloma
carcinoma of the gallbladder
cholangiocarcinoma
cowden syndrome
cystinuria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
liposarcoma
lymphangioleiomyomatosis
primary effusion lymphoma
severe combined immunodeficiency
von hippel-lindau disease
waldenström macroglobulinemia
wiskott-aldrich syndrome
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