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Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis.
[esophageal carcinoma]
Objective
.
Recently
,
many
studies
have
shown
that
microRNAs
(
miRNA
)
exhibit
altered
expression
in
various
cancers
and
may
play
an
important
role
as
prognostic
biomarker
of
cancers
.
We
performed
a
meta
-analysis
to
evaluate
the
impact
of
miR-
375
expression
in
solid
tumors
on
patients
'
overall
survival
(
OS
)
.
Methods
.
Studies
were
identified
by
searching
PubMed
,
Embace
,
and
Cochrane
Library
(
last
search
update
was
in
May
2014
)
and
were
assessed
by
further
quality
evaluation
.
The
pooled
hazard
ratios
(
HRs
)
with
95
%
confidence
intervals
(
CIs
)
for
total
and
stratified
analyses
were
calculated
to
investigate
the
association
between
miR-
375
expression
and
cancer
patients
OS
.
Results
.
Our
analysis
results
indicated
that
downregulation
of
miR-
375
predicted
poor
OS
(
HR
=
1
.
91
,
95
%
CI
1
.
48
-
2
.
45
,
P
<
0
.
001
)
.
Subgroup
analyses
showed
that
lower
expression
of
miR-
375
was
significantly
related
with
poor
OS
in
patients
with
esophageal
carcinoma
(
HR
=
2
.
24
,
95
%
CI
1
.
69
-
2
.
96
,
P
<
0
.
001
)
and
non-
small
-cell
lung
cancer
(
NSCLC
)
(
HR
=
1
.
71
,
95
%
CI
1
.
31
-
2
.
24
,
P
<
0
.
001
)
.
Conclusions
.
The
findings
from
this
meta
-analysis
suggest
that
miR-
375
expression
is
associated
with
OS
of
patients
with
malignant
tumors
and
could
be
a
useful
clinical
prognostic
biomarker
.
Diseases
Validation
Diseases presenting
"lung cancer"
symptom
adrenal incidentaloma
cholangiocarcinoma
cushing syndrome
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
kindler syndrome
liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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