Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Impact of histone deacetylase 1 and metastasis-associated gene 1 expression in esophageal carcinogenesis.
[esophageal adenocarcinoma]
Animal
models
are
important
for
the
development
of
novel
therapies
for
esophageal
cancer
.
Histone
deacetylase
1
(
HDAC
1
)
/
metastasis-associated
gene
(
MTA
1
)
complexes
inhibit
p
53
acetylation
and
thus
,
inhibit
p
53
-
induced
apoptosis
.
The
aim
of
the
present
study
was
to
evaluate
HDAC
1
and
MTA
1
expression
in
esophageal
carcinogenesis
in
rats
.
The
rats
underwent
a
total
gastrectomy
followed
by
esophagojejunostomy
to
induce
chronic
duodenal
content
reflux
esophagitis
.
The
rats
were
sacrificed
sequentially
at
20
,
30
,
40
and
50
weeks
post-surgery
and
the
esophagi
were
examined
.
Immunohistochemical
analysis
was
conducted
to
assess
the
expression
and
localization
of
HDAC
1
and
MTA
1
.
At
20
weeks
post-surgery
,
squamous
proliferative
hyperplasia
and
Barrett
's
metaplasia
(
BM
)
were
observed
.
While
,
adenocarcinoma-associated
BM
and
squamous
cell
carcinoma
were
observed
at
30
-
50
weeks
post-surgery
.
The
nuclear
expression
of
HDAC
1
and
MTA
1
was
observed
in
all
of
the
stages
of
squamous
carcinogenesis
and
adenocarcinogenesis
,
although
not
in
the
normal
esophageal
epithelium
.
The
expression
of
HDAC
1
and
MTA
1
may
be
involved
in
duodenoesophageal
reflux-induced
neoplastic
transformation
of
the
esophageal
mucosa
into
cancer
cells
with
squamous
and
adeno
differentiation
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated