Adrenal incidentaloma and the Janus Kinase 2 V617F mutation: A case-based review of the literature.

[adrenal incidentaloma]

Adrenal incidentaloma was detected in an 81 -year -old male patient and a 37 -year -old female patient who had been diagnosed with essential thrombocytosis . Each patient 's Janus Kinase 2 (JAK 2 ) V 617 F mutation was positive , and they were evaluated as having non-functional adrenal incidentaloma . The JAK 2 activates the signal transducers and activators of transcription (STAT ) proteins which then activate the phosphoinositol-3 kinases , Ras , mitogen-activated protein (MAP ) kinases , and transcription . Constitutive activation causes cell proliferation and dysregulation of apoptosis . It is thought that STAT 3 activation-mediated JAK family kinases have a central role in the solid tumor cell series . Permanent activation of STAT 3 and STAT 5 causes tumor cell proliferation , survival , metastasis , and an increase in tumor -mediated inflammation in solid and hematologic tumors . According to our literature screening , irregular JAK signaling , seen at the pathogenesis of many solid and hematologic tumors , has not been previously evaluated with regard to adrenal tumors . As a result , our cases are the first coexistence of JAK V 617 F mutation with adrenal incidentaloma in the literature . Because of this , we think that JAK 2 mutation must be evaluated to clarify the etiology of adrenal incidentalomas .

Diseases
Validation

Diseases presenting "tumor cell proliferation" symptom

adrenal incidentaloma

cholangiocarcinoma

esophageal carcinoma

hodgkin lymphoma, classical

kallmann syndrome

severe combined immunodeficiency

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